目的 建立牛黄清胃丸中掺伪品山麦冬的测定方法,以了解该制剂中麦冬掺伪情况。方法 采用液相色谱-串联电喷雾三重四级杆质谱(HPLC-MS-MS)法,多反应监测模式(MRM)对牛黄清胃丸中的山麦冬皂苷B和短葶山麦冬皂苷C进行分析。结果 18个批次牛黄清胃丸中15个批次均可检出山麦冬特征成分山麦冬皂苷B或短葶山麦冬皂苷C,含量为0.10~1.19 μg·g-1。结论 制剂中存在麦冬和山麦冬的混用情况。
Abstract
OBJECTIVE To establish the detection method of Liriopes Radix in Niuhuang Qingwei pills to uncover the adulteration situation of Ophiopogonis Radix in Niuhuang Qingwei pills. METHODS Liriopesides B and liriope muscari baily saponins C in Niuhuang Qingwei pills were analyzed by HPLC-MS-MS in MRM mode. RESULTS In the 18 batches of Niuhuang Qingwei pills, liriopesides B and liriope muscari baily saponins C, the index compounds of Liriopes Radix, were detected in 15 batches of samples in the concentrations of 0.10-1.19 μg·g-1. CONCLUSION The adulteration of Ophiopogonis Radix with Liriopes Radix should be paid more attention to.
关键词
牛黄清胃丸 /
麦冬 /
山麦冬 /
液质联用
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Key words
Niuhuang Qingwei pills /
Ophiopogonis Radix /
Liriopes Radix /
HPLC-MS/MS
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中图分类号：
R917
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